کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3275263 | 1208501 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Insulinorésistance et maladie d'Alzheimer
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Alzheimer's disease (AD) is a neurological disorder characterized by profound memory loss and progressive dementia. The best neuropathological correlate of cognitive decline in AD is a severe synapse loss in the hippocampus. Amyloid β-derived diffusible ligands (ADDLs) are now recognized as potent neurotoxics. Binding synapses, ADDLs inhibit long-term potentiation (a mechanism involved in memory) and induce synapse deterioration and progressive loss. Excess of ADDLs down-regulated synaptic insulin receptors. Deleterious effects of ADDLs on synapses can be completely prevented by insulin in mature cultures of hippocampal neurons. Insulin and insulin-sensitizing drugs (like thiazolidinediones) improve cognitive performance in mouse models of AD and in humans. Taken together, these data suggest that insulin signalling is a physiological protective mechanism against ADDLs neurotoxicity and that management of insulin resistance could be a novel strategy for the treatment of AD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Médecine des Maladies Métaboliques - Volume 3, Issue 4, September 2009, Pages 393-396
Journal: Médecine des Maladies Métaboliques - Volume 3, Issue 4, September 2009, Pages 393-396
نویسندگان
C. Amouyal, F. Andreelli,