کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3276279 1589667 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Vitamin A exerts its antiinflammatory activities in colitis through preservation of mitochondrial activity
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
Vitamin A exerts its antiinflammatory activities in colitis through preservation of mitochondrial activity
چکیده انگلیسی


• Vitamin A has protective antiinflammatory activity.
• Tissue mitochondrial DNA in vivo is highly susceptible and responds to inflammatory damage.
• Vitamin A protects colon mitochondria by upregulating the expression of mitochondrial transcription factors.

ObjectivesThe aim of this study was to assess the protective effects of vitamin A in a rat model of colitis to elucidate a possible mechanism of action.MethodsMale rats were fed for 21 d with either a normal diet or high vitamin A diet (5000 IU/d). On day 22, colitis was induced with 2,4,6-trinitrobenzenesulfonic acid (TNBS). Rats were sacrificed after 24 h and colonic tissue was removed for evaluation.ResultsMorphologically, in the supplemented group preservation of tissue architecture, no vasculitis or necroses were detected. Biochemically, decreased myeloperoxidase activity and protection of the mitochondria as evaluated by preserving tissue oxygen consumption, mitochondrial DNA, and expression of cytochrome c, was observed. Vitamin A supplementation also increased the levels of nuclear respiratory factor (NFR)-1 and mitochondrial transcription factor-A (TFAM) in normal colon tissue and in colon tissue under inflammatory conditions.ConclusionThe results indicate that tissue damage in colitis is accompanied by the arrest of mitochondrial respiration, loss of mitochondrial DNA, and the expression of mitochondrial proteins. Vitamin A effectively protects colon mitochondria by upregulation of mitochondrial transcription factors, NFR-1 and TFAM, and prevents inflammatory and necrotic changes in colitis. Vitamin A is therefore a potential therapeutic agent in inflammatory bowel disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition - Volume 31, Issues 11–12, November–December 2015, Pages 1402–1407
نویسندگان
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