کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3276664 1208585 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Leptin administration affects growth and skeletal development in a rat intrauterine growth restriction model: Preliminary study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
Leptin administration affects growth and skeletal development in a rat intrauterine growth restriction model: Preliminary study
چکیده انگلیسی

ObjectiveSkeletal abnormalities are one of the hallmarks of growth delay during gestation. The aim of this study was to determine changes induced by leptin in skeletal growth and development in a rat model of intrauterine growth retardation (IUGR) and to elucidate the possible underlying mechanisms.MethodsIntrauterine growth retardation was induced prepartum and the effects of leptin to mothers prenatally or to offspring postnatally were studied. Radii were harvested and tested mechanically and structurally. Tibias were evaluated for growth-plate morphometry.ResultsOn day 40 postpartum, total bone length and mineral density and tibial growth-plate width and numbers of cells within its zones of offspring treated with leptin were significantly greater than in the control group.ConclusionPostnatal leptin administration in an IUGR model improves the structural properties and elongation rate of bone. These findings could pave the way to preventing some phenotypic presentations of IUGR.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition - Volume 27, Issue 9, September 2011, Pages 973–977
نویسندگان
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