کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3281992 | 1209135 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Translating Molecular Physiology of Intestinal Transport Into Pharmacologic Treatment of Diarrhea: Stimulation of Na+ Absorption
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کلمات کلیدی
NHE3SGLT1CaSRcGMPORSSCFAcAMP - cAMPDRA - DRAGENaC - ENACCyclic adenosine monophosphate - آدنوزین مونوفسفات CyclicDiarrhea - اسهالshort-chain fatty acid - اسید چرب کوتاه مدتGastrointestinal - دستگاه گوارشIntestine - رودهWorld Health Organization - سازمان بهداشت جهانیOral rehydration solution - محلول دهانی مجدد دهانیBrush Border - مرز قلم موcyclic guanosine monophosphate - مونوفسفات گوانوزین چرخه ایdown-regulated in adenoma - پایین تنظیم شده در آدنومEpithelial Na+ channel - کانال نیکل Epithelial +WHO - کهCalcium-sensing receptor - گیرنده سنجش کلسیم
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Translating Molecular Physiology of Intestinal Transport Into Pharmacologic Treatment of Diarrhea: Stimulation of Na+ Absorption Translating Molecular Physiology of Intestinal Transport Into Pharmacologic Treatment of Diarrhea: Stimulation of Na+ Absorption](/preview/png/3281992.png)
چکیده انگلیسی
Diarrheal diseases remain a leading cause of morbidity and mortality for children in developing countries, while representing an important cause of morbidity worldwide. The World Health Organization recommended that low osmolarity oral rehydration solutions plus zinc save lives in patients with acute diarrhea, but there are no approved, safe drugs that have been shown to be effective against most causes of acute diarrhea. Identification of abnormalities in electrolyte handling by the intestine in diarrhea, including increased intestinal anion secretion and reduced Na+ absorption, suggest a number of potential drug targets. This is based on the view that successful drug therapy for diarrhea will result from correcting the abnormalities in electrolyte transport that are pathophysiologic for diarrhea. We review the molecular mechanisms of physiologic regulation of intestinal ion transport and changes that occur in diarrhea and the status of drugs being developed to correct the transport abnormalities in Na+ absorption that occur in diarrhea. Mechanisms of Cl- secretion and approaches to anti-Cl- secretory therapies of diarrhea are discussed in a companion review.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Gastroenterology and Hepatology - Volume 12, Issue 1, January 2014, Pages 27-31
Journal: Clinical Gastroenterology and Hepatology - Volume 12, Issue 1, January 2014, Pages 27-31
نویسندگان
Varsha Singh, Jianbo Yang, Tiane-e Chen, Nicholas C. Zachos, Olga Kovbasnjuk, Alan S. Verkman, Mark Donowitz,