کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3282854 | 1209161 | 2012 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Intestinal Permeability and Its Regulation by Zonulin: Diagnostic and Therapeutic Implications
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کلمات کلیدی
T1Dtight junctions - اتصالات محکمGut inflammation - التهاب خوبbacterial overgrowth - بیش از حد رشد باکتریAutoimmune disease - بیماری خودایمنیCeliac disease - بیماری سلیاکType 1 diabetes - دیابت نوع۱Obesity - مرض چاقیZot - مشیت الهیZonula occludens toxin - نوار ابزار بستن سمHaptoglobin - هاپتوگلوبینGluten - گلوتن
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
One of the most important and overlooked functions of the gastrointestinal tract is to provide a dynamic barrier to tightly controlled antigen trafficking through both the transcellular and paracellular pathways. Intercellular tight junctions (TJ) are the key structures regulating paracellular trafficking of macromolecules. Although steady progress has been made in understanding TJ ultrastructure, relatively little is known about their pathophysiological regulation. Our discovery of zonulin, the only known physiological modulator of intercellular TJ described so far, increased understanding of the intricate mechanisms that regulate gut permeability and led us to appreciate that its up-regulation in genetically susceptible individuals may lead to immune-mediated diseases. This information has translational implications, because the zonulin pathway is currently exploited to develop both diagnostic and therapeutic applications pertinent to a variety of immune-mediated diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Gastroenterology and Hepatology - Volume 10, Issue 10, October 2012, Pages 1096-1100
Journal: Clinical Gastroenterology and Hepatology - Volume 10, Issue 10, October 2012, Pages 1096-1100
نویسندگان
Alessio Fasano,