کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3285103 | 1209220 | 2007 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The Utility of Lens Culinaris Agglutinin-Reactive α-Fetoprotein in the Diagnosis of Hepatocellular Carcinoma: Evaluation in a United States Referral Population
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کلمات کلیدی
CLDROCAJCCobserved/expectedHCC - HCCO/E - O / Eα-fetoprotein - α-فتو پروتئینChronic liver disease - بیماری کبدی مزمنAFP - تست AFP یا آلفا فیتو پروتئینconfidence interval - فاصله اطمینانHepatocellular carcinoma - کارسینوم هپاتوسلولار(کارسینوم سلولهای استخوانی)American Joint Committee on Cancer - کمیته مشترک آمریکا در مورد سرطان
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Background & Aims: The percentage of Lens culinaris agglutinin-reactive (α)-fetoprotein (AFP-L3%) is proposed as a diagnostic and prognostic marker for hepatocellular carcinoma (HCC). We evaluated the utility of AFP-L3% for diagnosis of HCC in a US referral population. Methods: This retrospective study included 272 patients: 166 with HCC and 106 with benign liver disease (chronic liver disease, 77; benign liver mass, 29). The AFP-L3% was measured using a clinical auto-analyzer. Results: The AFP-L3% is not reported for a total α-fetoprotein (AFP) less than 10 ng/mL, and all patients with an AFP greater than 200 ng/mL had HCC; thus the AFP-L3% was noninformative for these patients. In patients with a total AFP of 10-200 ng/mL, an AFP-L3% greater than 10% had a sensitivity of 71% and a specificity of 63% for diagnosis of HCC. An AFP-L3% greater than 35% had a reduced sensitivity of 33%, but an increased specificity of 100%. The high specificity of the AFP-L3% cut-off of 35% allowed the confident diagnosis of an additional 10% of HCCs not diagnosed using an AFP cut-off of 200 ng/mL. After adjustment for AFP level, no association was observed between AFP-L3% and tumor size, stage, vascular invasion, grade, or survival. Conclusions: Patients with indeterminate total AFP values of 10-200 ng/mL present a diagnostic dilemma. We found that an AFP-L3% greater than 35% has 100% specificity for HCC in these patients. AFP-L3%, used in combination with AFP, may be a clinically useful adjunct marker for the diagnosis of HCC.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Gastroenterology and Hepatology - Volume 5, Issue 3, March 2007, Pages 394-402
Journal: Clinical Gastroenterology and Hepatology - Volume 5, Issue 3, March 2007, Pages 394-402
نویسندگان
Apinya Leerapun, Sri V. Suravarapu, John P. Bida, Raynell J. Clark, Elizabeth L. Sanders, Teresa A. Mettler, Linda M. Stadheim, Ileana Aderca, Catherine D. Moser, David M. Nagorney, Nicholas F. LaRusso, Piet C. de Groen, K.V. Narayanan Menon,