کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3285439 | 1209229 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Celiac Disease and Risk of Liver Disease: A General Population-Based Study
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کلمات کلیدی
SEIPSCPBCIPRSocioeconomic indexCeliac disease - بیماری سلیاکICD - دفیبریلاتورهای کاردیوورتر کاشتنیDiabetes mellitus - دیابت قندیPrimary biliary cirrhosis - سیروز صفراوی اولیهInternational Classification of Disease - طبقه بندی بین المللی بیماریconfidence interval - فاصله اطمینانhazard ratio - نسبت خطرLiver transplantation - پیوند کبدPrimary sclerosing cholangitis - کلانژیت اسکلروئیدی اولیه
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Background & Aims: Celiac disease (CD) is an important cause of hypertransaminasemia. CD might also be associated with severe forms of liver disease. We investigated the risk of liver disease in 13,818 patients with CD (1964-2003) and 66,584 age- and sex-matched reference individuals from a general population cohort. Methods:: We used Cox regression to estimate hazard ratios (HRs) for later liver disease and conditional logistic regression to estimate the risk of CD in individuals with liver disease before study entry. Results:: CD was associated with an increased risk of acute hepatitis (HR, 5.21; 95% confidence interval [CI], 1.88-14.40; P = .001), chronic hepatitis (HR, 5.84; 95% CI, 2.89-11.79; P < .001), primary sclerosing cholangitis (HR, 4.46; 95% CI, 2.50-7.98; P < .001), fatty liver (HR, 6.06; 95% CI, 1.35-27.16; P = .018), liver failure (HR, 3.30; 95% CI, 2.22-4.88; P < .001), liver cirrhosis or liver fibrosis (HR, 2.23; 95% CI, 1.34-3.72; P < .001), and primary biliary cirrhosis (HR, 10.16; 95% CI, 2.61-39.49; P < .001). There was no increased risk of liver transplantation (HR, 1.07; 95% CI, 0.12-9.62; P = .954). Adjustment for socioeconomic index or diabetes mellitus had no notable effect on the risk estimates. Prior liver disease was associated with a statistically significant 4-fold to 6-fold increased risk of later CD. Conclusion:: This study suggests that individuals with CD are at increased risk of both prior and subsequent liver disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Gastroenterology and Hepatology - Volume 5, Issue 1, January 2007, Pages 63-69.e1
Journal: Clinical Gastroenterology and Hepatology - Volume 5, Issue 1, January 2007, Pages 63-69.e1
نویسندگان
Jonas F. Ludvigsson, Peter Elfström, Ulrika BroomÃ, Anders Ekbom, Scott M. Montgomery,