کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3285696 | 1209237 | 2006 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Risk Factors for Diseases of Ileal Pouch-Anal Anastomosis After Restorative Proctocolectomy for Ulcerative Colitis
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کلمات کلیدی
PSCASCAPDAIanti-Saccharomyces cerevisiae antibodiesIPAA - ipaamiPS - IPSileal pouch–anal anastomosis - آناستوموز کمر درد مقعدیCrohn’s disease - بیماری کرونirritable pouch syndrome - سندرم کیسه تحریک پذیرCMV - سیتومگالوویروسcytomegalovirus - سیتومگالوویروسPouchitis Disease Activity Index - شاخص بیماری بیماری پوچیتسconfidence interval - فاصله اطمینانodds ratio - نسبت شانس هاPrimary sclerosing cholangitis - کلانژیت اسکلروئیدی اولیهUlcerative colitis - کولیت اولسراتیو
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Background & Aims: Although pouchitis is considered the most common adverse sequela of ileal pouch-anal anastomosis (IPAA), inflammatory and noninflammatory conditions other than pouchitis are increasingly being recognized. The risk factors for these non-pouchitis conditions, including Crohn's disease (CD) of the pouch, cuffitis, and irritable pouch syndrome (IPS), have not been studied. The aim of this study was to assess risk factors for inflammatory and noninflammatory diseases of IPAA in a tertiary care setting. Methods: The study consisted of 240 consecutive patients who were classified as having healthy pouches (N = 49), pouchitis (N = 61), CD of the pouch (N = 39), cuffitis (N = 41), or IPS (N =50). Demographic and clinical features were assessed to determine risk factors for each of these conditions by using logistic regression analysis. Results: Risk factors remaining in the final logistic regression models were for pouchitis: IPAA indication for dysplasia (odds ratio [OR], 3.89; 95% confidence interval [CI], 1.69-8.98), never having smoked (OR, 5.09; 95% CI, 1.01-25.69), no use of anti-anxiety agents (OR, 5.19; 95% CI, 1.45-18.59), or use of NSAIDs (OR, 3.24; 95% CI, 1.71-6.13); for CD of the pouch: a long duration of IPAA (OR, 1.20; 95% CI, 1.12-1.30) and current smoking (OR, 4.77; 95% CI, 1.39-16.25); for cuffitis: arthralgias (OR, 4.13; 95% CI, 1.91-8.94) and younger age (OR, 1.16; 95% CI, 1.01-1.33); and for IPS: use of antidepressants (OR, 4.17, 95% CI, 1.95-8.92) or anti-anxiety agents (OR, 3.21; 95% CI, 1.34-7.47). Conclusions: The majority of risk factors for the 4 inflammatory and noninflammatory conditions of IPAA are different, suggesting that each of these diseases has a different etiology and pathogenesis. The identification and modification of these risk factors might help patients and clinicians to make a preoperative decision for IPAA, reduce IPAA-related morbidity, and improve response to treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Gastroenterology and Hepatology - Volume 4, Issue 1, January 2006, Pages 81-89
Journal: Clinical Gastroenterology and Hepatology - Volume 4, Issue 1, January 2006, Pages 81-89
نویسندگان
Bo Shen, Victor W. Fazio, Feza H. Remzi, Aaron Brzezinski, Ana E. Bennett, Rocio Lopez, Jeffrey P. Hammel, Jean-Paul Achkar, Charles L. Bevins, Ian C. Lavery, Scott A. Strong, Conor P. Delaney, Wendy Liu, Marlene L. Bambrick, Kerry K. Sherman,