کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
328839 1433665 2006 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Salivary cortisol and memory function in human aging
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Salivary cortisol and memory function in human aging
چکیده انگلیسی

ObjectiveTo examine the association of salivary cortisol with cognitive changes in a 3 year longitudinal study. Previous studies have suggested that elevated glucocorticoid concentrations alter hippocampal neuronal morphology, inhibit neurogenesis, and impair cognition.MethodsSalivary cortisol samples were collected at home by 79 cognitively intact older persons (mean age 78 ± 7 years) at 08:00, 15:00 and 23:00 h, and collections were repeated annually for 3 years. Cognitive function was also assessed annually.ResultsThe mean cortisol level of samples taken at three times of day and the cortisol concentration at 23:00 h were significantly associated with poorer performance on tasks of declarative memory and executive function. Of 46 subjects who completed the entire 3 year study, higher initial cortisol concentration at 23:00 h predicted a decline in performance of delayed paragraph recall.ConclusionThese results partially confirm previous findings that high cortisol is associated with impaired declarative memory function in non-demented older persons. In addition, our data show that high salivary cortisol concentrations predict a decline in memory function over the next 3 years.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 27, Issue 11, November 2006, Pages 1705–1714
نویسندگان
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