کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
329156 | 1433601 | 2011 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A meta-analysis of diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease
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کلمات کلیدی
mild cognitive impairment - اختلال شناختی خفیفAlzheimer's disease - بیماری آلزایمرdiffusion tensor imaging - تصویربرداری تانسور انتشارMagnetic resonance imaging - تصویربرداری رزونانس مغناطیسیDementia - جنون یا زوال عقلMeta-analysis - فرا تحلیل white matter - ماده سفیدSystematic review - مرور سیستماتیک
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
We reviewed case-control studies of diffusion tensor imaging (DTI) in patients with Alzheimer's dementia (AD) and mild cognitive impairment (MCI), in order to establish the relative severity and location of white matter microstructural changes. EMBASE and MEDLINE were searched using the keywords, ([“diffusion tensor”] and [“Alzheimer*” or “mild cognitive impairment”]), as were reference lists of relevant papers. Forty-one diffusion tensor imaging studies contained data that were suitable for inclusion. Group means and standard deviations for fractional anisotropy and mean diffusivity, or p values from 2-sample tests, were extracted and pooled, using standard methods of meta-analysis and metaregression. Fractional anisotropy was decreased in AD in all regions except parietal white matter and internal capsule, while patients with MCI had lower values in all white matter regions except parietally and occipitally. Mean diffusivity was increased in AD in all regions, and in MCI in all but occipital and frontal regions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 32, Issue 12, December 2011, Pages 2322.e5-2322.e18
Journal: Neurobiology of Aging - Volume 32, Issue 12, December 2011, Pages 2322.e5-2322.e18
نویسندگان
Claire E. Sexton, Ukwuori G. Kalu, Nicola Filippini, Clare E. Mackay, Klaus P. Ebmeier,