SLAMF4 Is a Negative Regulator of Expansion of Cytotoxic Intraepithelial CD8+ T Cells That Maintains Homeostasis in the Small Intestine

In mice, the intestinal environment induces SLAMF4 expression and localization to the surface of CD8+ αβTCR+ IELs. Signaling via SLAMF4 controls expansion of cytotoxic CD8αβ+ IELs, which regulate the reversible depletion of lamina propria phagocytes and inflammation in the small intestine.