A Variant of Smurf2 Protects Mice Against Colitis-Associated Colon Cancer by Inducing Transforming Growth Factor β Signaling

T cell-specific ΔE2Smurf2 degrades wild-type Smurf2 and controls intestinal tumor growth in mice by up-regulating TGF-β receptor type II, reducing proliferation and production of proinflammatory cytokines.