Prolyl Hydroxylase-3 Is Down-regulated in Colorectal Cancer Cells and Inhibits IKKβ Independent of Hydroxylase Activity

PHD3 appears to be a tumor suppressor in colorectal cancer cells that inhibits IKKβ/NF-κB signaling, independent of its hydroxylase activity. Activation of NF-κB has been observed in colon cancer. Determination of PHD3 status could aid targeted therapy selection for patients with colorectal tumors that have increased NF-κB activity.