دانلود مقالات ISI درباره شامل + ترجمه فارسی

بیو تراپی در توسعه غیر بالینی: تقویت رابط بین ایمنی، فارماکوکینتیک، فارماکودینامیک و تولید

Biotherapeutics in non-clinical development: Strengthening the interface between safety, pharmacokinetics-pharmacodynamics and manufacturing

Keywords: شامل; Biotherapeutics; Gene and cell therapy; Pharmacokinetics; Non-clinical safety; Immunogenicity; Cross-reactive species; ATMP; advanced therapy medicinal products; CAR; chimeric antigen receptor; CD; cluster of differentiation; CMC; chemistry manufacturing

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

ملاحظات اخلاقی در تحقیقات مهندسی بافت: مطالعات موردی در ترجمه

Ethical considerations in tissue engineering research: Case studies in translation

Keywords: شامل; TESM; tissue engineered skeletal muscle; BAP; bioartificial pancreas; TM; therapeutic misconception; TD; translational distance; FIH; first-in-human; CRO; contract research organization; Human research ethics; Animal research ethics; Translational researc

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

ملاحظات اخلاقی و چالش های تحقیق اول در انسان

Ethical considerations and challenges in first-in-human research

Keywords: شامل; CFR; Code of Federal Regulations; COI; conflict of interest; FIH; first-in-human; GCP; good clinical practice; ICF; informed consent form; ICH; International Conference on Harmonization; IRB; institutional review board; TM; therapeutic misconception; TMis

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

بررسی عوامل هپاتوسیک در بیماری کبد و کارسینوم سلول های کبدی: درک در حال حاضر و جهت آینده

ReviewHypoxia inducible factors in liver disease and hepatocellular carcinoma: Current understanding and future directions

Keywords: شامل; HIFs; hypoxia inducible transcription factors; pO2; oxygen pressure; HREs; hypoxia responsive elements; PHD; prolyl hydroxylase domain-containing protein; FIH; factor inhibiting HIF; pVHL; von Hippel-Lindau tumour suppressor; mTOR; mechanistic target of r

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

ملاحظات برای ارزیابی ایمنی غیر بالینی کنجواب داروهای آنتیبادی برای سرطان

Considerations for the nonclinical safety evaluation of antibody drug conjugates for oncology

Keywords: شامل; ADC; antibody-drug conjugate; ADME; absorption, distribution, metabolism and elimination; EFD; embryofetal development; ELISA; enzyme-linked immunosorbent assay; FIH; first-in-human; GLP; Good Laboratory Practice; hERG; human ether-à-go-go related gene;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

هدف قرار دادن میکرو محیط زیست تومور برای طراحی و توسعه داروهای ضد انژیوژنیک جدید است که باعث توقف رشد تومور می شوند.

Targeting tumor micro-environment for design and development of novel anti-angiogenic agents arresting tumor growth

Keywords: شامل; Angiogenesis; Antiangiogenic agents; Angiogenic cytokines/peptides; EC; endothelial cells; VEGF; vascular endothelial growth factor; VEGF Receptor; VEGFR; FGF; fibroblast growth factor; EGF; epidermal growth factor; epidermal growth factor receptor; EGFR;

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2013 سفارش ترجمه

Functions and mechanisms of microRNA-31 in human cancers

Keywords: شامل; 3′-UTRs3′; -untranslated regions; ADC; Adenocarcinoma; BC; Breast cancer; BER; base excision repair; CDK4; cyclin-dependent kinase 4; CRC; Colorectal cancer; CRT; chemo-radiation therapy; C-TAD; COOH terminal transactivation domain; DHR1; dihydrorhoda

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

FIH permits NAA10 to catalyze the oxygen-dependent lysyl-acetylation of HIF-1α

Keywords: شامل; FIH; NAA10; HIF-1α; Tryptophan hydroxylation; Lysine acetylation;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Downregulation of HIF complex in the hypothalamus exacerbates diet-induced obesity

Keywords: شامل; ACTH; Adrenocorticotropic Hormone; ARC; Arcuate Nucleus; AgRP; Agouti-Related Peptide; ARNT; Aryl Hydrocarbon Receptor Nuclear Translocator; BAT; Brow Adipose Tissue; DIO; Diet-induced Obesity; FIH; Factor Inhibiting HIF-1α; GFAP; Glial Fibrillary Acidic

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Fatty Acids Prevent Hypoxia-Inducible Factor-1α Signaling Through Decreased Succinate in Diabetes

Keywords: شامل; cardiovascular disease; diabetes; fatty acids; metabolism; HIF-1α; hypoxia; ANOVA; analysis of variance; BSA; bovine serum albumin; DMF; dimethyl fumarate; DMOG; dimethyloxalylglycine; FA; fatty acid; FIH; factor inhibiting hypoxia-inducible factor; HIF;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2018 سفارش ترجمه

Hypoxia and HIF pathway in cancer and the placenta

Keywords: شامل; Oxygen; Hypoxia-inducible factor; Placenta; Trophoblast; Cancer; CCRCC; clear cell renal cell carcinoma; FasL; Fas ligand; FIH; factor inhibiting HIF; FLT1; fms-related tyrosine kinase 1; HIF; hypoxia-inducible factor; HLA; human leukocyte antigen; MHC; m

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

The functional interplay between the HIF pathway and the ubiquitin system - more than a one-way road

Keywords: شامل; Hypoxia; PHD; FIH; Deubiquitinase; E3 ligase; Inflammation;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

An FDA oncology analysis of CD3 bispecific constructs and first-in-human dose selection

Keywords: شامل; CD3 bispecific; MABEL; First-in-human dose; Oncology drug development; FIH; first-in-human; CRA; cytokine release assay; CRS; cytokine release syndrome; GLP; good laboratory practice; HHD; highest human dose; HNSTD; highest non-severely toxic dose; IB; In

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Ascorbic acid, but not dehydroascorbic acid increases intracellular vitamin C content to decrease Hypoxia Inducible Factor -1 alpha activity and reduce malignant potential in human melanoma

Keywords: شامل; BRAF; Murine sarcoma viral (v-raf) oncogene homolog B1; HIF-1α; Hypoxia inducible factor-1 alpha; PHD; prolyl hydroxylase; FIH; Factor Inhibiting HIF; AA; Ascorbic acid; A2P; Ascorbate 2-phosphate; DHA; Dehydroascorbic acid; EDHB; Ethyl 3, 4-dihydroxbeno

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Hypoxia Inducible Factor (HIF) Hydroxylases as Regulators of Intestinal Epithelial Barrier Function

Keywords: شامل; Epithelial Barrier; Inflammatory Bowel Disease; Hypoxia; Hypoxia-Inducible Factor (HIF) Hydroxylases; CD; Crohn's disease; DMOG; dimethyloxalylglycine; DSS; dextran sodium sulfate; FIH; factor inhibiting hypoxia-inducible factor; HIF; hypoxia-inducible

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

The cytoplasmic domain of MT1-MMP is dispensable for migration augmentation but necessary to mediate viability of MCF-7 breast cancer cells

Keywords: شامل; BM; Basement Membrane; CAM; ChorioAllantoic Membrane; CD; Cytoplasmic Domain; CD-44; Cluster of Differentiation 44; CM; Conditioned Media; ECM; Extracellular Matrix; ERK; Extracellular Regulated Kinase; F-actin; Filamentous Actin; FIH; Factor Inhibiting H

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Current nonclinical testing paradigms in support of safe clinical trials: An IQ Consortium DruSafe perspective

Keywords: شامل; Bial; FIH; Phase 1; Nonclinical safety; Discovery toxicology; IQ; DruSafe; Attrition;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Study on the role of Hsa-miR-31-5p in hypertrophic scar formation and the mechanism

Keywords: شامل; HS; Hypertrophic scars; ECM; Extracellular matrix; HIF1α; Hypoxia inducible factor1 α; HSFBs; Hypertrophic scar fibroblasts; VEGF; Vascular endothelial growth factor; TIMP-1; Tissue inhibitors of metalloproteinase; TAD; Transcriptional activation domain

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2017 سفارش ترجمه

NMR studies of the non-haem Fe(II) and 2-oxoglutarate-dependent oxygenases

Keywords: شامل; 2OG; 2-Oxoglutarate; BBOX; γ-Butyrobetaine hydroxylase; CODD; C-terminal oxygen-dependent degradation domain; COSY; Correlation spectroscopy; DSBH; Double-stranded β-helix; EFE; Ethylene-forming enzyme; FIH; Factor-inhibiting hypoxia-inducible factor; H

دانلود رایگان متن کامل مقاله ISI 54 صفحه سال انتشار : 2017 سفارش ترجمه

The prospective IQ-CSRC trial: A prototype early clinical proarrhythmia assessment investigation for replacing the ICH E14 thorough QTc (TQT) study

Keywords: شامل; AP; cardiac action potential; CiPA; comprehensive in vitro proarrhythmia assay; CSRC; Cardiac Safety Research Consortium; Cmax; maximal plasma concentration; CTWG; clinical translational working group; DRest; rate-normalized Tpeak − Tend = Tpe inter

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

An FDA oncology analysis of immune activating products and first-in-human dose selection

Keywords: شامل; MABEL; Immune oncology; First-in-human dose; ADCC; antibody-dependent cellular cytotoxicity; CRA; cytokine release assay; CRS; cytokine release syndrome; DLT; dose limiting toxicity; EMA; European Medicines Agency; FIH; first-in-human; HHD; highest human

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

CITED2 controls the hypoxic signaling by snatching p300 from the two distinct activation domains of HIF-1α

Keywords: شامل; HIF-1α; hypoxia-inducible factor 1α; CITED2; CBP/p300-interacting transactivator with an ED-rich tail 2; FIH; factor inhibiting HIF; VHL; von Hippel-Lindau; NAD; N-terminal transactivation domain; CAD; C-terminal transactivation domain; CH1/2; Cystein

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Targeting the ROS-HIF-1-endothelin axis as a therapeutic approach for the treatment of obstructive sleep apnea-related cardiovascular complications

Keywords: شامل; Obstructive sleep apnea; Cardiovascular disease; Intermittent hypoxia; Oxidative stress; Hypoxia inducible factor-1; Endothelin-1; AHI; apnea-hypopnea index; ARBs; angiotensin II receptor blockers; BP; blood pressure; CAD; coronary artery disease; CamK;

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2016 سفارش ترجمه

An FDA oncology analysis of antibody-drug conjugates

Keywords: شامل; AD; acceptable dose; ADC; antibody-drug conjugate; ADCC; antibody-dependent cellular cytotoxicity; FIH; first-in-human; HNSTD; highest non-severely toxic dose; ICH; International Conference on Harmonization; LC/MS; liquid chromatography/mass spectrometry;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Hypoxia inducible factor 1α contributes to regulation of autophagy in retinal detachment

Keywords: شامل; Retinal detachment; Hypoxia-inducible factor; Photoreceptors; Autophagy; Hypoxia; PR; photoreceptors; RPE; retinal pigment epithelium; HIF; hypoxia-inducible factors; PHD; prolyl-hydroxyl domain; FIH; factoring inhibiting HIF; BNIP3; Bcl-2/E1B 19 kDa-int

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Spatial variation of PM elemental composition between and within 20 European study areas - Results of the ESCAPE project

Keywords: شامل; AUV; Vorarlberg, Austria; BNL; Belgium & the Netherlands; DCO; Copenhagen, Denmark; FIH; Helsinki/Turku, Finland; FPA; Paris, France; GMU; Munich/Augsburg, Germany; GRA; Athens, Greece; GRH; Heraklion, Greece; GRU; Ruhr Area, Germany; HUG; Gyor, Hungary;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

A novel effect of DMOG on cell metabolism: direct inhibition of mitochondrial function precedes HIF target gene expression

Keywords: شامل; α-KG; α-ketoglutarate; AMPK; AMP-activated protein kinase; DMSO; dimethyl sulfoxide; EGFP; enhanced green fluorescence protein; EPAS1; endothelial PAS domain-containing protein 1 (known as HIF-2α); EPO; erythropoietin; esiRNA; endoribonuclease-prepared

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Differential contribution of key metabolic substrates and cellular oxygen in HIF signalling

Keywords: شامل; ACC; acetyl-CoA carboxylase; Akt; protein kinase B (PKB); α-KG; α-ketoglutarate; AMPK; AMP-activated protein kinase; BPTES; (bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide; DIC; differential interference contrast; DMEM; Dulbecco׳s Modifie

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2015 سفارش ترجمه

14th Annual Meeting of the Safety Pharmacology Society: Threading through peripheral and central nervous system presentations

Keywords: شامل; Aβ; Aβ-amyloid protein; AANEM; American Academy of Neuromuscular and Electrodiagnostic Medicine; AAN; American Academy of Neurology; AD; Alzheimer's Disease; API; Alzheimer's Prevention Initiative-APOE4; ADF; Abuse Deterrent Formulations; ADNI; Alzheime

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2015 سفارش ترجمه

Pharmacoperones and the calcium sensing receptor: Exogenous and endogenous regulators

Keywords: شامل; ADH; autosomal dominant hypocalcemia; CaSR; calcium sensing receptor; xCT; cystine-glutamate transporter; DHPs; dihydropyridines; EAAT; excitatory amino acid transporter; EGFR; endothelial growth factor receptor; ER; endoplasmic reticulum; ERK1/2; extrace

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

The active role of vitamin C in mammalian iron metabolism: Much more than just enhanced iron absorption!

Keywords: شامل; Asc; l--ascorbate; CGcytb; chromaffin granule cytochrome b561; Dcytb; duodenal cytochrome b561; DHA; dehydroascorbate; DMT1; divalent metal transporter isoform 1; FBXL5; F-box and leucine-rich repeat protein 5; FIH; factor inhibiting HIF; FPN1; ferroporti

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2014 سفارش ترجمه

Recombinant human serum amyloid P in healthy volunteers and patients with pulmonary fibrosis

Keywords: شامل; Pulmonary fibrosis; Serum amyloid P; PRM-151; First-in-human clinical trial; Pentraxin-2; Macrophage; Fibrocyte; AE; adverse events; ELISA; enzyme linked immunoassay; ERS/ATS; European Respiratory Society/American Thoracic Society; FACS; fluorescence acti

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

A mechanistic overview of TET-mediated 5-methylcytosine oxidation

Keywords: شامل; TET; Ten-Eleven Translocation; 5mC; 5-methylcytosine; 5hmC; 5-hydroxymethylcytosine; 5fC; 5-formylcytosine; 5caC; 5-carboxylcytosine; 2OG; 2-oxoglutarate; KDM; histone lysine demethylase; PHD; Prolyl-hydroxylase-domain; FIH; Factor-inhibiting-HIF; Epigene

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Cloning and characterization of hypoxia-inducible factor-1 subunits from Ascaris suum - A parasitic nematode highly adapted to changes of oxygen conditions during its life cycle

Keywords: شامل; ARNT; aryl hydrocarbon receptor nuclear translocator; bHLH; basic helix-loop-helix; CAD; C-terminal activation domain; C-TAD; C-terminal transactivation domain; FIH; factor inhibiting HIF; HIF; hypoxia-inducible factor; HRE; hypoxia-responsive element; N-

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Chromatin as an oxygen sensor and active player in the hypoxia response

Keywords: شامل; HIF; Hypoxia inducible factor; ARNT; Aryl hydrocarbon nuclear translocator; VHL; von Hippel Lindau; PHD; Prolyl-hydroxylase; FIH; Factor inhibiting HIF; ChIP; Chromatin immunoprecipitation; SWI/SNF; Switch/Sucrose NonFermentable; ISWI; Imitation switch; C

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase

Keywords: شامل; ARD; adult Refsum disease; DSBH; double-stranded beta-helix; EctD; ectoine hydroxylase; FIH; factor inhibiting hypoxia-inducible factor; 2OG; 2-oxoglutarate; PAHX; phytanoyl-CoA hydroxylase; PHD2; prolyl hydroxylase isoform 2; SyrB2; 2OG dependent halogen

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Prolyl Hydroxylase-3 Is Down-regulated in Colorectal Cancer Cells and Inhibits IKKβ Independent of Hydroxylase Activity

Keywords: شامل; DMOG; dimethyloxaloylglycine; FIH; factor inhibiting HIF; GST; glutathione S-transferase; HIF; hypoxia inducible factor; IκB; inhibitor of nuclear factor-κB; IKK; IκB kinase; NF; nuclear factor; PHD; prolyl hydroxylase;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Identification and characterization of the hypoxia-responsive element in human stanniocalcin-1 gene

Keywords: شامل; FIH; p300; siRNA; Promoter

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Interactions between Notch- and hypoxia-induced transcriptomes in embryonic stem cells

Keywords: شامل; Micro-array; Transcriptome; Gamma secretase; HIF; FIH; CSL; ES cell

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2010 سفارش ترجمه

Transcriptional activation of hypoxia-inducible factor-1α by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1

Keywords: شامل; HIF-1; hypoxia-inducible factor-1; ODD; oxygen-dependent degradation; FIH-1; factor inhibiting HIF-1; HDAC; histone deacetylase; HRE; hypoxia-response element; C-TAD; C-terminal activating domain; ID; inhibitory domain; TSA; trichostatin A; pVHL; von Hipp

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Modulation of CYP1A1 and CYP2B1 expression upon cell cycle progression in cultures of primary rat hepatocytes

Keywords: شامل; C/EBP; CCAAT/enhancer binding protein; CDK1; cyclin-dependent kinase 1; CYP; cytochrome P450; BSA; bovine serum albumin; DSM; differentiation stimulating medium; EGF; epidermal growth factor; EROD; 7-ethoxyresorufin-O-deethylase; FBS; fetal bovine serum;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Commentary on “Hypoxia, hypoxic signaling, tissue damage, and detection of reactive oxygen species (ROS)”

Keywords: شامل; ROS; reactive oxygen species; XOR; xanthine oxidoreductase; HIFs; hypoxia-inducible factor; PHDs; prolyl-4-hydroxylases; FIH; factor inhibiting HIF; GAGs; glycosoaminoglycans;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2006 سفارش ترجمه

Antioxidant defenses in the preterm lung: role for hypoxia-inducible factors in BPD?

Keywords: شامل; Ang-1 to -4; angiopoietin 1 to 4; AOE(s); antioxidant enzyme(s); ARD-1; HIF acetylase; ARNT; aryl hydrocarbon nuclear translocator; BPD; bronchopulmonary dysplasia; CAT; catalase; CTAD and NTAD; C- and N-terminal transactivation domain, respectively; CuZn

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2005 سفارش ترجمه