CITED2 controls the hypoxic signaling by snatching p300 from the two distinct activation domains of HIF-1α

► p300 CH1 and CH2 both participate in HIF-1α NAD-driven transcription. ► In hypoxia, CITED2 inactivates HIF-1α by interfering with NAD binding to CH1. ► In normoxia, pVHL inhibits NAD activity by interfering with NAD binding to CH3.