کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9018422 | 1128703 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antioxidant defenses in the preterm lung: role for hypoxia-inducible factors in BPD?
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کلمات کلیدی
extracellular SODDMOGFlt-1pVHLG6PDHManganese SODPECAM-1DeferoxamineHREPDGFARNTγ-GTHK-IINOS-2MnSODET-1BPDCATDFOγ-GCLGSHGPXFMS-like tyrosine kinase 1EPOdimethyloxaloylglycineCuZnSODGLUT-1IGF-1ecSOD - ecsodaryl hydrocarbon nuclear translocator - اتمسفر هسته ای آرویل هیدروکربنerythropoietin - اریتروپویتینendothelin 1 - اندوتلین 1Bronchopulmonary dysplasia - دیسپلازی ریویFIH - شاملfactor inhibiting HIF - عامل مهار HIFhypoxia response element - عنصر پاسخ هیپوکسیplatelet derived growth factor - فاکتور رشد حاصل از پلاکتinsulin-like growth factor 1 - فاکتور رشد مانند انسولین 1platelet endothelial cell adhesion molecule 1 - مولکول چسبندگی سلول اندوتلیال پلاکت 1nitric oxide synthase 2 - نیتریک اکسید سنتاز 2heme oxygenase - همگام اکسژنازhexokinase II - هگزوکیناز IICatalase - کاتالازGamma glutamyl transpeptidase - گاما گلوتامیل ترانسپپتیدازGlutathione - گلوتاتیونglutathione reductase - گلوتاتیون ردوکتازglutathione peroxidase - گلوتاتیون پراکسیدازglucose transporter 1 - گلوکز 1glucose 6-phosphate dehydrogenase - گلوکز 6-فسفات دهیدروژناز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Antioxidant defenses in the preterm lung: role for hypoxia-inducible factors in BPD? Antioxidant defenses in the preterm lung: role for hypoxia-inducible factors in BPD?](/preview/png/9018422.png)
چکیده انگلیسی
Pulmonary antioxidants and their therapeutic implications have been extensively studied during past decades. The purpose of this review is to briefly summarize the key findings of these studies as well as to elaborate on some novel approaches with respect to potential preventive treatments for neonatal chronic lung disease bronchopulmonary dysplasia (BPD). Such new ideas include, for example, modification of transcription factors governing the hypoxic response pathways, important in angiogenesis, cell survival, and glycolytic responses. The fundamental strategy behind that approach is that fetal lung normally develops under hypoxic conditions and that this hypoxic, growth-favoring environment is interrupted by a premature birth. Importantly, during fetal lung development, alveolar development appears to be dependent on vascular development. Therefore, enhancement of signaling factors that occur during hypoxic fetal life ('continued fetal life ex utero'), including angiogenic responses, could potentially lead to improved lung growth and thereby alleviate the alveolar and vascular hypoplasia characteristic of BPD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology and Applied Pharmacology - Volume 203, Issue 2, 1 March 2005, Pages 177-188
Journal: Toxicology and Applied Pharmacology - Volume 203, Issue 2, 1 March 2005, Pages 177-188
نویسندگان
Tiina M. Asikainen, Carl W. White,