Keywords: پرولیل هیدروکسیلاز; PDC; pyruvate dehydrogenase complex; TCA; tricarboxylic acid cycle; PKM2; pyruvate dehydrogenase kinase 2; HMGB1; high mobility group box 1 protein; LPS; lipopolysaccharide; SDH; succinate dehydrogenase; ETC; electron transport chain; PHD; prolyl hydroxyl
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Keywords: پرولیل هیدروکسیلاز; AMPK; AMP-activated protein kinase; ARF6; ADP-ribosylation factor 6; AKT; protein kinase B; BBB; blood brain barrier; bFGF; b-fibroblast growth factors; b-FGFR; b-fibroblast growth factors receptor; ccRCC; clear cell renal cell carcinoma; ECs; endothelial
Keywords: پرولیل هیدروکسیلاز; AML; Acute myeloid leukemia; BBB; blood-brain barrier; BCAAs; branched-chain amino acids; ecDNA; extrachromosomal DNA; FH; fumarate hydratase; GBM; glioblastoma multiforme; HIF1/2; hypoxia-inducible factor 1/2; IDH1/2; isocitrate dehydrogenases 1/2; LXR;
Keywords: پرولیل هیدروکسیلاز; 5-HT; 5-hydroxytryptamine; AA; arachidonic acid; ACh; acetylcholine; ACTH; adrenocorticotrophic hormone; AD; Alzheimer's Disease; ADP; adenosine diphosphate; Aβ; amyloid β; AMP; adenosine monophosphate; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepro
Keywords: پرولیل هیدروکسیلاز; Hypoxia; Protein hydroxylation; Prolyl hydroxylase; Hypoxia-inducible factor; Transcription; Cancer;
Keywords: پرولیل هیدروکسیلاز; Prolyl Hydroxylase; EGLN; Hypoxia; HIF; Chick embryo;
Keywords: پرولیل هیدروکسیلاز; Hypoxia; HIF-1; Prolyl hydroxylase; DMOG; JNJ-42041935; Embryonic stem cellsATP, adenosine triphosphate; DMOG, dimethyloxaloylglycine; EdU, 5-ethynyl-2′-deoxyuridine; ESC, embryonic stem cells; FIH, factor inhibiting HIF; HIF, hypoxia inducible factor; JN
Keywords: پرولیل هیدروکسیلاز; Ca2+ channel; K+ channel; Ca2+-activated Clâ channel; Transcription; Pre-mRNA splicing; Protein degradation; AD; Alzheimer's disease; ADPR; ADP ribose; AITC; allyl isothiocyanate; AKAP; A-kinase anchoring protein; AMPK; 5â² AMP-activated protein kinase
Keywords: پرولیل هیدروکسیلاز; ARNT; aryl hydrocarbon nuclear translocator; BCRP; breast cancer resistant protein; CAD; C-terminal activation domain; CAIX; carbonic anhydrase IX; CAV1; caveolin-1; ccRCC; clear cell renal cell carcinoma; CSC; cancer stem cells; DAG; diacylglycerol; DUSP
Keywords: پرولیل هیدروکسیلاز; 4E-BP; 4E binding protein; AP-1; activator protein-1; Ad-AH; EBV-negative adenocarcinoma cell line; Akt; serine/threonine kinase; ARNT; aryl hydrocarbon receptor nuclear translocator; ATP/ADP; adenosine tri- or diphosphate; CAIX and CAXII; carbonic anhydr
Keywords: پرولیل هیدروکسیلاز; HIF-1; hypoxia-inducible factor-1; VHL; von Hippel-Lindau; PHD; prolyl hydroxylase; HTS; high-throughput screening; NBS; N-bromosuccinimide; MNBA; 2-methyl-6-nitrobenzoic anhydride; DIBAL; diisobutylaluminum hydride; VEGF-PLAP; vascular endothelial grow
Keywords: پرولیل هیدروکسیلاز; Mouse Model; CD; UC; Oxygen; CD; Crohn's disease; DMOG; dimethyloxaloylglycine; DSS; dextran sulfate sodium; EPAS1; endothelial PAS domain protein 1; HIF; hypoxia-inducible factor; IBD; inflammatory bowel disease; IL; interleukin; MAZ; myc-associated zinc
Keywords: پرولیل هیدروکسیلاز; 2D-DIGE; 2-dimensional differential gel electrophoresis; ACAD9; acyl-CoA dehydrogenase 9; AMPK; AMP-dependent protein kinase; ATG; autophagy-related protein; ATP5; ATP synthase subunit; BNIP3; BCL2/adenovirus E1B 19Â kDa protein-interacting protein 3; BNI
Keywords: پرولیل هیدروکسیلاز; ACD; anemia of chronic disease; AID; absolute iron deficiency; ARE; antioxidant-responsive elements; asc; ascorbic acid; DMT1; divalent metal transporter 1; eNOS; endothelial nitric oxide synthase; EPO; erythropoietin; FBXL5; F-box and leucine-rich repeat
Hypoxia Inducible Factors Modify Collagen I Fibers in MDA-MB-231 Triple Negative Breast Cancer Xenografts
Keywords: پرولیل هیدروکسیلاز; Col1; Collagen I; DAB; 3,3â²-diaminobenzedine; DS; Double Silenced; ECM; Extracellular Matrix; HIF; Hypoxia Inducible Factor; H&E; Hematoxylin and eosin; LOX; Lysyl Oxidase; MMP; Matrix Metalloproteinase; MT-MMP; Membrane-Type Matrix Metalloproteinase; P
The Hypoxia Mimetic Protocatechuic Acid Ethyl Ester Inhibits Synaptic Signaling and Plasticity in the Rat Hippocampus
Keywords: پرولیل هیدروکسیلاز; 2-OG; 2-oxoglutarate; aCSF; artificial cerebrospinal fluid; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; AP-5; (2R)-amino-5-phosphonovaleric acid; CA1; Cornu Ammonis 1; DFO; desferrioxamine; DIV; days in vitro; DMOG; dimethyloxal
Ascorbic acid, but not dehydroascorbic acid increases intracellular vitamin C content to decrease Hypoxia Inducible Factor -1 alpha activity and reduce malignant potential in human melanoma
Keywords: پرولیل هیدروکسیلاز; BRAF; Murine sarcoma viral (v-raf) oncogene homolog B1; HIF-1α; Hypoxia inducible factor-1 alpha; PHD; prolyl hydroxylase; FIH; Factor Inhibiting HIF; AA; Ascorbic acid; A2P; Ascorbate 2-phosphate; DHA; Dehydroascorbic acid; EDHB; Ethyl 3, 4-dihydroxbeno
Pyrithione Zn selectively inhibits hypoxia-inducible factor prolyl hydroxylase PHD3
Keywords: پرولیل هیدروکسیلاز; Prolyl hydroxylase; Pyrithione Zn; Hypoxia-inducible factor; Isoform selective inhibitor; HIF; hypoxia-inducible factor; PHD; HIF prolyl hydroxylase; 2-OG; 2-oxoglutarate; VHL; von Hippel-Lindau tumor suppressor; HCLK2; human homologue of the c.elegans bi
Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-κB-dependent manner
Keywords: پرولیل هیدروکسیلاز; Prolyl hydroxylase; NF-κB; Apoptosis; Hypoxia;
Catalytic-independent inhibition of cIAP1-mediated RIP1 ubiquitination by EGLN3
Keywords: پرولیل هیدروکسیلاز; cIAP; cellular inhibitor of apoptosis protein; DFX; Desferrioxamine; DMOG; dimethyl oxalylglycine; EGLN; Caenorhabditis elegans gene egl-9; HA; hemagglutinin; HEK293 cells; human embryonic kidney 293 cells; IB; immunoblotting; IP; immunoprecipitation; HIF
Hypoxic inhibition of JMJD3 reduces H3K27me3 demethylation and induction of the STAT6 target gene CCL18
Keywords: پرولیل هیدروکسیلاز; C/EBPβ; CCAAT/enhancer binding protein (C/EBP), beta; c-myc; MYC = v-myc avian myelocytomatosis viral oncogene homolog; CBP; CREBBP = CREB binding protein; CCL18; chemokine (CC motif) ligand 18 (pulmonary and activation-regulated); CHX; cycloheximid;
Targeting respiratory complex I to prevent the Warburg effect
Keywords: پرولیل هیدروکسیلاز; OXPHOS; oxidative phosphorylation; CI; complex I; ROS; reactive oxygen species; TCA; tricarboxylic acid; PARP1; poly (ADP ribose) polymerase 1; AMPK; AMP activated kinase; mTORC1; mammalian target of rapamycin complex 1; HIF1α; hypoxia inducible factor 1
Deletion of prolyl hydroxylase domain proteins (PHD1, PHD3) stabilizes hypoxia inducible factor-1 alpha, promotes neovascularization, and improves perfusion in a murine model of hind-limb ischemia
Keywords: پرولیل هیدروکسیلاز; Hindlimb ischemia; Prolyl hydroxylase; HIF; VEGF; Bcl-2;
Apelin/APJ signaling in hypoxia-related diseases
Keywords: پرولیل هیدروکسیلاز; HIF-1α; hypoxia-inducible factor-1 alpha; Ang-II; angiotensin-II; HREs; hypoxia-responsive elements; PHD; prolyl hydroxylase; CoCl2; cobalt chloride; H/R; hypoxia/re-oxygenation; HIFP4H-2; hypoxia-inducible factor prolyl 4-hydroxylase 2; H/I; hypoxic/isc
Upregulation of HIF-2α induced by sorafenib contributes to the resistance by activating the TGF-α/EGFR pathway in hepatocellular carcinoma cells
Keywords: پرولیل هیدروکسیلاز; ANOVA; analysis of variance; ARNT; aryl hydrocarbon receptor nuclear translocator; CCK-8; Cell Counting Kit-8; CHX; cycloheximide; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; EGFR; epidermal growth factor receptor; ERK; extracellul
Modeling the dynamics of hypoxia inducible factor-1α (HIF-1α) within single cells and 3D cell culture systems
Keywords: پرولیل هیدروکسیلاز; Hypoxia; HIF (hypoxia inducible factor); Prolyl hydroxylase; Spheroids; Mathematical modeling; Oxygen nanoprobes;
Cloning and characterization of hypoxia-inducible factor-1 subunits from Ascaris suum - A parasitic nematode highly adapted to changes of oxygen conditions during its life cycle
Keywords: پرولیل هیدروکسیلاز; ARNT; aryl hydrocarbon receptor nuclear translocator; bHLH; basic helix-loop-helix; CAD; C-terminal activation domain; C-TAD; C-terminal transactivation domain; FIH; factor inhibiting HIF; HIF; hypoxia-inducible factor; HRE; hypoxia-responsive element; N-
Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: The role of hypoxia inducible factor 1 pathway
Keywords: پرولیل هیدروکسیلاز; ALT; alanine aminotransferase; AST; aminotransferase; BUN; blood urea nitrogen; CRE; creatinine; Ctsd; cathepsin D; FACS; flow cytometry analysis; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; HCC; hepatocellular carcinoma; Hb; hemoglobins; HIF-1; hypo
Genotype and Tumor Locus Determine Expression Profile of Pseudohypoxic Pheochromocytomas and Paragangliomas
Keywords: پرولیل هیدروکسیلاز; AT; abdominal/thoracic; CSS; Carney-Stratakis Syndrome; HIF2α; hypoxia-inducible factor 2α; HN; head/neck; IPA; Ingenuity Pathway Analysis; NF1/NF1; neurofibromatosis 1 syndrome/gene; OXPHOS; oxidative phosphorylation; PAMR; prediction analysis for micr
Metabolic reprogramming in cancer: Unraveling the role of glutamine in tumorigenesis
Keywords: پرولیل هیدروکسیلاز; Gls; glutaminase; GDH; glutamate dehydrogenase; PC; pyruvate carboxylase; GFAT; fructose-6-phosphate amido-transferase; GSH; glutathione; GlcNAc; N-acetyl-d-glucosamine; PRPP; 5-phospho-α-d-ribosyl 1-pyrophosphate; AOA; aminooxyacetate; EAA; essential am
Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1α
Keywords: پرولیل هیدروکسیلاز; Focal cerebral ischemia; Hypoxia inducible factor; Prolyl hydroxylase; preconditioning; Postconditioning; Dimethyloxaloylglycine
Prolyl hydroxylase in human corpora lutea during menstrual cycle and early pregnancy
Keywords: پرولیل هیدروکسیلاز; Prolyl hydroxylase; immunohistochemistry; human corpus luteum
Adaptation to moderate hypoxia protects cortical neurons against ischemia-reperfusion injury and excitotoxicity independently of HIF-1α
Keywords: پرولیل هیدروکسیلاز; Hypoxia; Adaptation; Ischemia; Reperfusion; Neuroprotection; Hypoxia-inducible factor; Prolyl hydroxylase; Excitotoxicity; Glutamate;
Uncovering the role of hypoxia inducible factor-1α in skin carcinogenesis
Keywords: پرولیل هیدروکسیلاز; Bax; Bcl-2-associated X protein; BCC; Basal cell carcinoma; Bcl-2; B cell lymphoma; Bcl-xL; B-cell lymphoma-extra large; BNIP3; BCL2/adenovirus E1B 19Â kDa protein-interacting protein 3; CMM; Cutaneous malignant melanoma; CBP; cyclic-AMP response element
Novel molecular targets of the neuroprotective/neurorescue multimodal iron chelating drug M30 in the mouse brain
Keywords: پرولیل هیدروکسیلاز; multifunctional drug; iron chelation; hypoxia-inducible factor; brain-derived neurotrophic factor; pro-survival signaling pathways; systemic chronic administration; AD; Alzheimer's disease; BDNF; brain-derived neurotrophic factor; DFO; deferoxamine; dNTP;
Preconditioning protects against oxidative injury involving hypoxia-inducible factor-1 and vascular endothelial growth factor in cultured astrocytes
Keywords: پرولیل هیدروکسیلاز; Tolerance; Neuroprotection; Oxidative stress; HIF-1 (hypoxia-inducible factor-1) target gene; Prolyl hydroxylase; Desferrioxamine
Loss of Prolyl Hydroxylase-1 Protects Against Colitis Through Reduced Epithelial Cell Apoptosis and Increased Barrier Function
Keywords: پرولیل هیدروکسیلاز; Colitis; Hydroxylase; Apoptosis; Hypoxia; DMOG; dimethyl-oxalylglycine; DSS; dextran sulphate sodium; FITC; fluorescein isothiocyanate; HIF; hypoxia inducible factor; IL-1β; interleukin-1 β; PBS; phosphate-buffered saline; PHD; prolyl hydroxylase; siRNA
Retention of prolyl hydroxylase PHD2 in the cytoplasm prevents PHD2-induced anchorage-independent carcinoma cell growth
Keywords: پرولیل هیدروکسیلاز; EGLN; Egl-9 homologue; HIF-1; hypoxia-inducible factor-1; HNSCC; head and neck squamous cell carcinoma; PHD; prolyl hydroxylation domain protein; pVHL; von Hippel-Lindau protein; TMA; tissue microarray; RT-PCR; real-time PCR; Colon carcinoma; HIF-1α; Hyp
Prolyl Hydroxylase-3 Is Down-regulated in Colorectal Cancer Cells and Inhibits IKKβ Independent of Hydroxylase Activity
Keywords: پرولیل هیدروکسیلاز; DMOG; dimethyloxaloylglycine; FIH; factor inhibiting HIF; GST; glutathione S-transferase; HIF; hypoxia inducible factor; IκB; inhibitor of nuclear factor-κB; IKK; IκB kinase; NF; nuclear factor; PHD; prolyl hydroxylase;
Cellular NeuroscienceResearch PaperHydroxylase inhibition reduces synaptic transmission and protects against a glutamate-induced ischemia in the CA1 region of the rat hippocampus
Keywords: پرولیل هیدروکسیلاز; prolyl hydroxylase; dimethyloxallyl glycine; hypoxia inducible factor-1 alpha; hippocampus; excitatory postsynaptic potential; paired pulse facilitation; aCSF; artificial cerebrospinal fluid; A1R; adenosine 1 receptor; CREB; cAMP response element binding
Angiogenesis and Current Antiangiogenic Strategies for the Treatment of Cancer
Keywords: پرولیل هیدروکسیلاز; bFGF; basic fibroblast growth factor; DLL4; Notch ligand delta-like 4; ERK; extracellular signal-regulated kinase; FDA; Food and Drug Administration; HIF; hypoxia-inducible factor; MAPK; mitogen-activated protein kinase; MMP; matrix metalloproteinase; m
Role of the intracellular localization of HIF-prolyl hydroxylases
Keywords: پرولیل هیدروکسیلاز; Hypoxia; Prolyl hydroxylase; HIF-1
Prolyl hydroxylase inhibition attenuates post-ischemic cardiac injury via induction of endoplasmic reticulum stress genes
Keywords: پرولیل هیدروکسیلاز; Ischemia–reperfusion; Myocardium; Prolyl hydroxylase; Unfolded protein response
Intermittent hypoxia regulates RNA polymerase II in hippocampus and prefrontal cortex
Keywords: پرولیل هیدروکسیلاز; intermittent hypoxia; hippocampus; prolyl hydroxylase; RNA polymerase II; PC12 cells; CTD; C-terminal domain; Cul2; cullin 2; cyt; cytoplasmic extract; HA; hemagglutinin; HP; hydroxylated proline; IH; intermittent hypoxia; nuc; nuclear extract; PC12; pheo
Kinetic characterization and identification of a novel inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 using a time-resolved fluorescence resonance energy transfer-based assay technology
Keywords: پرولیل هیدروکسیلاز; 2-Oxoglutarate; HIF; Non-heme iron; Oxygen; PHD2; Prolyl hydroxylase; Von Hippel–Lindau protein; vHL
Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1α prolyl hydroxylase-2 inhibitors
Keywords: پرولیل هیدروکسیلاز; PHD-2; HIF-1a; Prolyl hydroxylase; Hypoxia; Normoxia; Aza-benzimidazole
Concomitant inhibition of prolyl hydroxylases and ROCK initiates differentiation of mesenchymal stem cells and PC12 towards the neuronal lineage
Keywords: پرولیل هیدروکسیلاز; Mesenchymal stem cell; Prolyl hydroxylase; Neural differentiation; PC12; HIF-1
Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition
Keywords: پرولیل هیدروکسیلاز; ANOVA; analysis of variance; ELISA; enzyme-linked immunoabsorbent assay; EPO; erythropoietin; FITC; fluorescein isothiocyanate; HIF-1α; hypoxia-inducible factor 1α; HRE; hypoxia response element; IFNγ; interferon-γ; LPS; lipopolysaccharide; PCR; polym
Reactive oxygen species and cellular oxygen sensing
Keywords: پرولیل هیدروکسیلاز; Reactive oxygen species; Prolyl hydroxylase; Mitochondria; Cellular oxygen sensing; Hypoxia; Hypoxia inducible factorHIF, hypoxia-inducible factor; ROS, reactive oxygen species; FNR, fumarate and nitrate reduction; pVHL, von Hippel-Lindau protein; PHD, pr
Gallate, the component of HIF-inducing catechins, inhibits HIF prolyl hydroxylase
Keywords: پرولیل هیدروکسیلاز; Gallic acid; n-Propyl gallate; Hypoxia inducible factor; Prolyl hydroxylase; Chelation; Ferrous ion; Ubiquitin