کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3297172 | 1209881 | 2008 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
TNF Receptor Type I-Dependent Activation of Innate Responses to Reduce Intestinal Damage-Associated Mortality
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کلمات کلیدی
c-Jun NH2-terminal kinaseTNFSAPKRAGTNFRPI3KCECTCrJnkDSSMAPK - MAPKTUNEL - تونلColonic Epithelial Cells - سلولهای اپیتلیال کولونdextran sodium sulfate - سولفات سدیم سدیمtumor necrosis factor - فاکتور نکروز تومورphosphoinositide-3 kinase - فسفونیوزیتید-3 کینازRecombination Activating Gene - فعال سازی مجدد ژنLamina propria - لامینا پروپریاbone marrow - مغز استخوانknockout - ناکاوتwild-type - نوع وحشیAntibody - پادتَن یا آنتیبادیmitogen-activated protein kinase - پروتئین کیناز فعال با mitogenStress-activated protein kinase - پروتئین کیناز فعال شده با استرسT-cell receptor - گیرنده لنفوسیت TTumor necrosis factor receptors - گیرنده های فاکتور نکروز تومور
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Background & Aims: Ligation of tumor necrosis factor (TNF) receptors (TNFRs) with TNF plays a critical role in the pathogenesis of human inflammatory bowel disease (IBD). However, it remains unclear which cell types activated through TNFR-associated signaling cascades are involved in the pathogenesis of colitis. Methods: Recombination activating gene-1 (RAG) knockout (KO) (no T or B cells)-based TNFR double and triple KO mice were generated. Bone marrow (BM) chimera mice in which BM-derived myeloid cells, but not colonic epithelial cells (CECs), express TNFRs were also generated. Colitis was induced by administration of dextran sodium sulfate (DSS) in distilled water. Murine lines and chimeras were assessed for disease severity, histopathology, apoptotic cell rate, epithelial proliferation, and bacterial invasion rate. Results: Following DSS administration, mice lacking both RAG and TNFR1 exhibited a high mortality (>80%) rate with an impaired CEC regeneration compared with RAG KO and RAG Ã TNFR2 double KO (DKO) mice. Transplantation of RAG KO-derived BM cells restored CEC regeneration and rescued the majority of recipient RAG Ã TNFR1 DKO mice from DSS-induced mortality. After BM transplantation, RAG Ã TNFR1 DKO mice exhibited an increased rate of apoptosis in the colonic lamina propria macrophages in association with the activation of caspases. In addition, BM reconstitution directly or indirectly enhanced the proliferation of CECs by activating mitogen-activated protein kinase and phosphoinositide-3 kinase/Akt pathways. Conclusions: TNFR1-signaling cascade in colonic myeloid lineage cells contributes to the suppression of acute damage-associated mortality presumably by controlling CEC homeostasis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 134, Issue 2, February 2008, Pages 470-480
Journal: Gastroenterology - Volume 134, Issue 2, February 2008, Pages 470-480
نویسندگان
Emiko Mizoguchi, Yuriko Hachiya, Mayumi Kawada, Katsuya Nagatani, Atsuhiro Ogawa, Ken Sugimoto, Atsushi Mizoguchi, Daniel K. Podolsky,