کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3299620 | 1209933 | 2006 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Contribution of Sensory Neurons to Sex Difference in the Development of Stress-Induced Gastric Mucosal Injury in Mice
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کلمات کلیدی
WiRDRGVanilloid receptor-1PGI2CGRPPGPOVXdorsal root ganglion - گانگلیون ریشه پشتیMPO - DFOWater-immersion restraint stress - استرس مهار آب غوطه ورOvariectomy - اوفورکتومی، تخمدان برداریUlcer index - شاخص زخمmyeloperoxidase - میلوپراکسیداز polymerase chain reaction - واکنش زنجیره ای پلیمرازPCR - واکنش زنجیرهٔ پلیمرازprotein gene product - پروتئین محصول ژنprostacyclin - پروستاسیکلینcalcitonin gene-related peptide - پپتید مرتبط با ژن کلسی تونین
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Background & Aims: Sensory neurons play a critical role in reducing stress-induced gastric mucosal injury by releasing calcitonin gene-related peptide (CGRP) through an increase in gastric mucosal levels of prostacyclin (PGI2). Because estrogen enhances nerve growth factor-mediated CGRP production in sensory neurons, we hypothesized that stress-induced gastric mucosal injury occurs less in females than in males. Methods: Gastric ulcer index, gastric myeloperoxidase activity, and gastric tissue levels of CGRP and 6-keto-PGF1α, a stable metabolite of PGI2, were determined in male and female wild-type (CGRP+/+) mice and CGRP knockout (CGRPâ/â) mice subjected to water-immersion restraint stress. Results: In CGRP+/+ mice, ulcer index and myeloperoxidase activities were lower and gastric tissue levels of CGRP and 6-keto-PGF1α were higher in female mice than in male mice, but there were no such sex differences in CGRPâ/âmice. Sex differences in CGRP+/+ mice were eliminated by pretreatment with SB366791 (500 μg/kg intraperitoneally), a vanilloid receptor antagonist, and by ovariectomy. Reversal of sex differences by ovariectomy was not observed in female CGRP+/+ mice with estradiol replacement (1 mg  · kgâ1 · wkâ1 for 3 weeks). Levels of CGRP messenger RNA in dorsal root ganglion neurons isolated from female CGRP+/+ mice were decreased by ovariectomy, and these decreases were reversed by estradiol replacement. Conclusions: Estrogen-mediated increases in CGRP levels in sensory neurons might contribute to reduce stress-induced gastric mucosal injury by attenuating inflammatory responses. This might at least partly explain the sex difference observed in the development of stress-induced gastric mucosal injury in mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 131, Issue 6, December 2006, Pages 1826-1834
Journal: Gastroenterology - Volume 131, Issue 6, December 2006, Pages 1826-1834
نویسندگان
Nobuhiko Shimozawa, Kenji Okajima, Naoaki Harada, Masatoku Arai, Yusuke Ishida, Shoichi Shimada, Hiroki Kurihara, Naomi Nakagata,