کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3316767 | 1211545 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Calcium signaling and secretion in cholangiocytes
ترجمه فارسی عنوان
سیگنالینگ و ترشح کلسیم در کلنگیوسیت ها
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
چکیده انگلیسی
Alcoholic hepatitis affects up to one-third of individuals who abuse alcohol and can be associated with high mortality. Although this disorder is characterized by hepatocellular damage, steatosis and neutrophil infiltration, recent evidence suggests that cholestasis or impaired bile secretion may be a frequent occurrence as well. Bile secretion results from the concerted activity of hepatocytes and cholangiocytes, the epithelial cells that line the bile ducts. Hepatocytes secrete bile acids and conjugated products into the bile canaliculi, which then are modified by cholangiocytes through secretion of bicarbonate and water to give rise to the final secreted bile. Here the molecular mechanisms regulating bile secretion in cholangiocytes are reviewed. Moreover, we discuss how the expression of intracellular Ca2+ channels might be regulated in cholangiocytes, plus evidence that components of the Ca2+ signaling machinery are altered in a range of cholestatic diseases of the bile ducts.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pancreatology - Volume 15, Issue 4, Supplement, July 2015, Pages S44-S48
Journal: Pancreatology - Volume 15, Issue 4, Supplement, July 2015, Pages S44-S48
نویسندگان
Mateus T. Guerra, Michael H. Nathanson,