Quinone oxidoreductase (NQO1) gene polymorphism may not confer a susceptibility to mood disorders

Quinone oxidoreductase (NQO1) plays a key role in the cellular antioxidant defense by detoxifying quinine derivatives. Case–control association study of the possible relationship between the NQO1 gene polymorphism and mood disorders (patients with major depressive disorder, n = 61; patients with bipolar I disorder, n = 80; control, n = 106) was carried out using PCR-based techniques. These preliminary results showed that the NQO1 gene polymorphism was not related to a susceptibility to mood disorders.