The CYP1A2 –163C>A polymorphism is associated with clozapine-induced generalized tonic-clonic seizures in Brazilian schizophrenia patients

We evaluated two polymorphisms at CYP1A2 (⁎1C and ⁎1F) in a sample of 108 European-derived patients with schizophrenia and their influence on the pro-convulsive effect of clozapine. We found the ⁎1F/⁎1F genotype to be significantly associated with seizures, and no relationship was observed with combinations of ⁎1F and ⁎1C alleles.