کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
332680 545743 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pooling pharmacogenetic studies on the serotonin transporter: A mega-analysis
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Pooling pharmacogenetic studies on the serotonin transporter: A mega-analysis
چکیده انگلیسی

Pharmacogenetic studies on antidepressants have reported an association between the promoter of the serotonin transporter gene (SERTPR) and response to antidepressant treatment. In the present study, individual subject data from three pharmacogenetic studies on SERTPR were pooled (‘mega-analysis’) to investigate the role of this gene in the antidepressant activity of selective serotonin reuptake inhibitors (SSRIs). A group of 548 patients who were treated with different SSRIs in a double blind design were included; the severity of depressive symptoms was weekly assessed with the Hamilton Rating Scale for Depression. SERPR allelic variants were determined in each subject using a PCR-based technique. In the whole sample, subjects with SERPR⁎ l/l variants showed a significantly better response to treatment, and this effect was independent from analyzed demographic and clinical variables but was not uniform across samples. This result supports the involvement of the SERTPR gene in response to antidepressant treatments.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 145, Issue 1, 29 November 2006, Pages 61–65
نویسندگان
, , , , ,