Viral hepatitis B, C and HIV coinfection: Evaluation of some immunological and epidemiological aspects

AimStudy is focused on assessing the immune status and viral load in patients infected with HIV in association with viral hepatitis B and C.BackgroundBloodburne infections currently represents a major public health problem that requires resolving. The association of HIV with other infectious diseases is significant, especially for assessment and evaluation of clinical and epidemiological features, treatment and prevention. Parenteral viral hepatitis have some common epidemiological features including HIV transmission routes, maintain risk prevention measures, etc., and on this basis is very important to study clinical and epidemiological features of HIV infection in association with hepatitis B and C, fully optimize the epidemiological surveillance. The need for this study also can be justified by the fact that Moldova is an endemic area for morbidity by hepatitis B, C and D.Materials and MethodsEpidemiological analysis of immunological and virological features of patients infected with HIV in coinfection with viral hepatitis B and C was performed based on a case-control epidemiological study. The study included epidemiological and laboratory methods for determination of influence of HCV and HBV presence on HIV evolution. Levels of CD4, CD8 cells and HIV viral load were determined in both control and experimental group.ResultsEvaluation of the study results show that the amount of T lymphocytes CD4, CD4/CD8 ratio and HIV viral load in patients with coinfections HIV/HCV, HIV/HBV and HIV/HBV/HCV did not differ significantly from the same clues to patients in the control group.The results of epidemiological analysis of the presence of viral hepatitis markers in HIV infected patients depending on clinical stages of HIV demonstrated that patients with HCV and HCV/HBV are more advanced clinical stage of HIV infection.ConclusionIt is important to initiate additional studies on the influence of hepatitis B and C in people infected with HIV on clinical progression of HIV for optimization of epidemiological surveillance measures, especially in endemic for viral hepatitis countries.