کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3332411 1213083 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A sequential approach to identify the offending medication in HIV sero-positive patients having hypersensitivity to fixed dose combination of HAART
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
A sequential approach to identify the offending medication in HIV sero-positive patients having hypersensitivity to fixed dose combination of HAART
چکیده انگلیسی

AimHypersensitivity to the anti-retroviral agents is a common problem encountered in the treatment of HIV/AIDS patients. However, in resource-limited settings, where only fixed-dose combinations of the drugs are the only available option and expensive facilities of pharmacological analysis are not available, isolating the offending agent can be a challenging task.BackgroundWe, at our centre, follow a protocol to isolate such offending drug – a protocol of gradual de-challenge and re-challenge – by a method of exclusion.Materials and MethodsHere, we have described a series of four cases, providing examples of usage of our own protocol to isolate the offending drug by a method of exclusion.Results and ConclusionIn a resource-limited setting, where we have to use fixed-dose combination of anti-retroviral agents, management of a patient with drug hypersensitivity is a problem. Our protocol of systematic de-challenge and re-challenge, as exemplified in these cases, can be of help where expensive facilities are not available.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: HIV & AIDS Review - Volume 13, Issue 4, 2014, Pages 125–130
نویسندگان
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