Nephrotoxicity of Tenofovir true or myth?

SummaryAmong HIV (Human Immunodeficiency Virus) infected patients, combined antiretroviral therapy (cART) has significantly altered the treatment efficiency and life expectancy. Some antiretroviral agents may have influence on the function of various organs. We describe some aspects of the influence of kidney functions as Tenofovir (TDF) widely used as NRTI (Nucleoside Reverse Transcriptase Inhibitor).Renal sufficiency is one of the main problems through the initiation and continuation of each treatment and is influenced by age, gender, coexisting diseases or concomitant medication. Understanding all mechanisms and actions of antiretroviral's in correlation with general status is key for safe and effective treatment.