کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3332596 | 1213105 | 2007 | 4 صفحه PDF | دانلود رایگان |
SummaryThe necessity of concomitant treatment of tuberculosis and HIV infection in the same patient creates a therapeutic challenge due to drug-drug interactions. The most problematic issue is coadministration of rifamycins with protease inhibitor (PI) – based antiretroviral regimens. One of the PIs, commonly used in Poland is lopinavir/ritonavir (LPV/r), and the only rifamycin directly available is rifampin. It is well known that rifampin dramatically decreases lopinavir plasma levels. In the view of different studies, coadministration of LPV/r with rifampin, despite attempts to compensate the interaction with dosage adjustment or additional ritonavir, is not advisable because of toxicity. In such situations, rifabutin should be a drug of choice. It can be taken as 1/4 of normal dosage. LPV/r dosage does not need to be changed. In Poland, rifabutin can be obtained through special importing procedure.
Journal: HIV & AIDS Review - Volume 6, Issue 2, 2007, Pages 15–18