کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
333379 | 545917 | 2015 | 11 صفحه PDF | دانلود رایگان |
• Over 2/3s of Major Depressive Disorder cases do not achieve remission on initial treatment.
• Urgent need to identify effective next step treatments for MDD.
• Switching to bupropion-SR vs. augmenting with bupropion-SR or aripiprazole.
• Compare 12-week remission and relapse for up to 6 months after remission.
• Seven methodological issues to balance efficacy and effectiveness.
Because two-thirds of patients with Major Depressive Disorder do not achieve remission with their first antidepressant, we designed a trial of three “next-step” strategies: switching to another antidepressant (bupropion-SR) or augmenting the current antidepressant with either another antidepressant (bupropion-SR) or with an atypical antipsychotic (aripiprazole). The study will compare 12-week remission rates and, among those who have at least a partial response, relapse rates for up to 6 months of additional treatment. We review seven key efficacy/effectiveness design decisions in this mixed “efficacy-effectiveness” trial.
Journal: Psychiatry Research - Volume 229, Issue 3, 30 October 2015, Pages 760–770