Evaluation of relationship between GRM3 polymorphisms and cognitive function in schizophrenia of Han Chinese

• Significant association was found between rs12704290 in GRM3 gene and schizophrenia.
• A three-SNP LD block (rs6465084-rs2228595-rs12704290)spanning GRM3Δ4 splice site was significantly associated with schizophrenia.
• Interaction between the signigicantly associated LD block and cognitive function was found in our schizophrenia patients.

Recently, the novel SNP rs12704290 in GRM3 was identified in a genome-wide association study on schizophrenia susceptibility. Our study was to investigate the association of 29 selected SNPs (including rs12704290) with schizophrenia and to evaluate any possible relationship between them and cognition related to schizophrenia. The SNPs were analyzed in 1115 unrelated schizophrenic patients and 2289 healthy controls. The results showed significant associations between these SNPs and schizophrenia as well as with changes in cognition.