کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3334326 1213437 2016 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lynch Syndrome : Female Genital Tract Cancer Diagnosis and Screening
ترجمه فارسی عنوان
سندرم لینچ: تشخیص و تشخیص سرطان دستگاه تناسلی زنان
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
چکیده انگلیسی

Lynch syndrome is responsible for approximately 5% of endometrial cancers and 1% of ovarian cancers. The molecular basis for Lynch syndrome is a heritable functional deficiency in the DNA mismatch repair system, typically due to a germline mutation. This review discusses the rationales and relative merits of current Lynch syndrome screening tests for endometrial and ovarian cancers and provides pathologists with an informed algorithmic approach to Lynch syndrome testing in gynecologic cancers. Pitfalls in test interpretation and strategies to resolve discordant test results are presented. The potential role for next-generation sequencing panels in future screening efforts is discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Surgical Pathology Clinics - Volume 9, Issue 2, June 2016, Pages 201–214
نویسندگان
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