کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3334329 | 1213437 | 2016 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Peutz-Jeghers Syndrome : Pathobiology, Pathologic Manifestations, and Suggestions for Recommending Genetic Testing in Pathology Reports
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
هماتولوژی
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چکیده انگلیسی
Peutz-Jeghers syndrome (PJS), in most cases, is attributed to mutation in STK11/LKB1 and is clinically characterized by gastrointestinal hamartomatous polyposis, mucocutaneous pigmentation, and predisposition to certain neoplasms. There are currently no recommended gynecologic screening or clinical surveillance guidelines beyond those recommended for the general population; however, cervical cytology samples must be examined with a high level of suspicion for cervical adenocarcinoma. It is considered prudent to note the established association with PJS and recommend referral for genetic counseling. Complete surgical excision after a diagnosis of atypical lobular endocervical glandular hyperplasia is recommended.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Surgical Pathology Clinics - Volume 9, Issue 2, June 2016, Pages 243–268
Journal: Surgical Pathology Clinics - Volume 9, Issue 2, June 2016, Pages 243–268
نویسندگان
Emily E.K. Meserve, Marisa R. Nucci,