کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3334416 1213441 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genetics of Gastrointestinal Stromal Tumors : A Heterogeneous Family of Tumors?
ترجمه فارسی عنوان
ژنتیک تومورهای استرومائی دستگاه گوارش: یک خانواده ناهمگن از تومورها؟
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
چکیده انگلیسی

Approximately 85–90% of adult gastrointestinal stromal tumors (GISTs) harbor KIT and PDGFRA mutations. The remaining cases, including the majority of pediatric GISTs, lack these mutations, and have been designated as KIT/PDGFRA wild-type (WT) GISTs. Nearly 15% of WT GISTs harbor BRAF mutations, while others arise in patients with type I neurofibromatosis. Recent work has confirmed that 20–40% of KIT/PDGFRA WT GISTs show loss of function of succinate dehydrogenase complex. Less than 5% of GISTs lack known molecular alterations (“quadruple-negative” GISTs). Thus, it is important to consider genotyping these tumors to help better define their clinical behavior and therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Surgical Pathology Clinics - Volume 8, Issue 3, September 2015, Pages 515–524
نویسندگان
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