کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
333869 545983 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Refining clinical judgment of treatment outcome in obsessive–compulsive disorder
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Refining clinical judgment of treatment outcome in obsessive–compulsive disorder
چکیده انگلیسی

This research aimed to provide clinicians and investigators with optimal treatment outcome criteria for accurately predicting response and remission in both research studies and clinical practice. Data from 153 adult OCD outpatients (ages 18–79) who had participated in a treatment outcome study were examined. Signal detection analysis was conducted to compare levels of Yale–Brown Obsessive Compulsive Scale (Y-BOCS) symptom percent reductions and post treatment absolute scores with Clinical Global Impression (CGI) ratings of symptom improvement and severity. Optimal cutoff criteria were based on sensitivity, specificity and efficiency and were assessed via the Quality Receiver Operating Characteristic curve. A Y-BOCS reduction of 45% was observed to be the most efficient for predicting response in research trials, whereas a reduction of 35% may be optimal for clinical use. A 55% Y-BOCS reduction was determined to be the optimal cutoff for predicting remission in both clinical and research settings. A Y-BOCS absolute raw score of 12 or less was optimal for predicting remission in a clinical setting and a raw score of 14 or below was most favorable in research trials. This research provides the first empirical contrast of optimal outcome criteria in OCD based on differing ideals of both research and practice.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 185, Issue 3, 28 February 2011, Pages 394–401
نویسندگان
, , , , , ,