| کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
|---|---|---|---|---|
| 3341334 | 1214201 | 2016 | 36 صفحه PDF | دانلود رایگان |
• The role of ion channels in immune responses is highlighted.
• Ion channels in the development of autoimmunity are portrayed.
• Possible means to develop ion channel mediated therapeutic interventions are listed.
Ion channels are integral membrane proteins that orchestrate the passage of ions across the cell membrane and thus regulate various key physiological processes of the living system. The stringently regulated expression and function of these channels hold a pivotal role in the development and execution of various cellular functions. Malfunction of these channels results in debilitating diseases collectively termed channelopathies. In this review, we highlight the role of these proteins in the immune system with special emphasis on the development of autoimmunity. The role of ion channels in various autoimmune diseases is also listed out. This comprehensive review summarizes the ion channels that could be used as molecular targets in the development of new therapeutics against autoimmune disorders.
Journal: Autoimmunity Reviews - Volume 15, Issue 7, July 2016, Pages 585–620