کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3341438 | 1214211 | 2016 | 14 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Induction of regulatory T cells: A role for probiotics and prebiotics to suppress autoimmunity Induction of regulatory T cells: A role for probiotics and prebiotics to suppress autoimmunity](/preview/png/3341438.png)
Regulatory T cells (Tregs) are comprised of a heterogeneous population of cells that play a vital role in suppressing inflammation and maintaining immune tolerance. Given the crucial role of Tregs in maintaining immune homeostasis, it is probably not surprising that many microbial species and their metabolites have the potential to induce Tregs. There is now great interest in the therapeutic potential of probiotics and prebiotics based strategies for a range of autoimmune disorders. This review will summarise recent findings concerning the role of probiotics and prebiotics in induction of Tregs to ameliorate the autoimmune conditions. In addition, the article is focused to explain the different mechanisms of Treg induction and function by these probiotics and prebiotics, based on the available studies till date. The article further proposes that induction of Tregs by probiotics and prebiotics could lead to the development of new therapeutic approach towards curbing the autoimmune response and as an alternative to detrimental immunosuppressive drugs.
Journal: Autoimmunity Reviews - Volume 15, Issue 4, April 2016, Pages 379–392