کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3341545 | 1214219 | 2014 | 9 صفحه PDF | دانلود رایگان |

• Autoantibodies are involved in the pathogenesis of immune-mediated neuropathies.
• Here, we review the importance of autoantibodies to peripheral nerve proteins.
• Cell adhesion molecules are immune targets in subgroups of patients.
• Finding novel biomarkers is useful to improve the treatment of these pathologies.
Guillain–Barré syndrome is classified into acute inflammatory demyelinating polyneuropathy and acute motor axonal neuropathy. Whereas autoantibodies to GM1 or GD1a induce the development of acute motor axonal neuropathy, pathogenic autoantibodies have yet to be identified in acute inflammatory demyelinating polyneuropathy and chronic inflammatory demyelinating polyneuropathy. This review highlights the importance of autoantibodies to peripheral nerve proteins in the physiopathology of acute and chronic inflammatory demyelinating polyneuropathies. Moreover, we listed up other potential antigens, which may become helpful biomarkers for acquired, dysimmune demyelinating neuropathies based on their critical functions during myelination and their implications in hereditary demyelinating neuropathies.
Journal: Autoimmunity Reviews - Volume 13, Issue 10, October 2014, Pages 1070–1078