کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3341680 1591147 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
IgM predominance in autoimmune disease: Genetics and gender
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
IgM predominance in autoimmune disease: Genetics and gender
چکیده انگلیسی

The role of specific immunoglobulin isotypes in human autoimmune disease has long attracted attention. Indeed, the presence of a polyclonal gammopathy is well known in a variety of systemic autoimmune diseases and is likely the result of chronic inflammation. However, in specific clinical situations, patients manifest isolated and elevated IgM levels, but normal IgG and IgA. The pathophysiology of this elevation and the clinical significance have been elusive. However, the relationships between specific genes and hyper-IgM are now very well defined, as it has been documented in primary hyper IgM syndromes. In this review we present data on clinical diseases with characteristic IgM abnormalities, including primary and secondary hyper IgM syndromes, autoimmune hemolytic anemia, cryoglobulinemia, primary biliary cirrhosis and multiple sclerosis and place the data in the perspective of the normal maturation of the immune response, including somatic mutation and genetic rearrangement.


► Increased IgM is found in Ig switch recombination deficiencies.
► Autoimmunity is present in all forms of the hyper-IgM syndrome.
► The pathophysiology of IgM in human autoimmune disease is poorly understood.
► Specific autoimmune diseases are characterized by increased IgM levels.
► IgM regulates autoimmunity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autoimmunity Reviews - Volume 11, Issues 6–7, May 2012, Pages A404–A412
نویسندگان
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