Systemic juvenile idiopathic arthritis

Systemic juvenile idiopathic arthritis (sJIA) sets well apart from all the other forms of JIA. Several observations show that sJIA is etiopathogenically different from all the other forms of JIA and has a prominent autoinflammatory component. A major role in the pathogenesis is played by two proinflammatory cytokines, interleukin-6 and interleukin-1. The specific inhibition of these two cytokines is going to change not only the therapeutic approach to the disease but also, presumably, its long term prognosis.

► sJIA is sets well apart from all the other forms of JIA.
► Autoinflammatory mechanisms seem to play a major role in the pathogenesis.
► IL-1 and IL-6 blockers are effective and will change the long term prognosis of JIA.