ANCA in the diagnosis of neutrophil-mediated inflammation

►ANCA belong among NSA. ►NSA observed on ethanol-fixed granulocytes can have cytoplasmic and/or nuclear targets. ►The terms C-ANCA and P-ANCA and A-ANCA should only be used for IIFA. ►The terms anti-PR3, anti-MPO, etc. should be used for other than IIFA techniques. ►The most frequently occurring ANCA/NSA is A-ANCA in routine clinical laboratories.