کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3342003 1214258 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Follicular helper T cells in systemic lupus erythematosus: A potential therapeutic target
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Follicular helper T cells in systemic lupus erythematosus: A potential therapeutic target
چکیده انگلیسی

Systemic lupus erythematosus (SLE) is an autoimmune disease characteristic of the immune complex–induced chronic inflammatory damages. The high-affinity pathogenic autoantibodies, which primarily originate from the self-reactive B cells underwent somatic hypermutation and class switch, principally but not exclusively, in germinal centers, contribute substantially to the inflammatory damages of multiple organs in SLE. Follicular helper T (TFH) cells constitute a distinct CD4+ T helper population beyond the Th1/Th2 paradigm. TFH cells can be critical for providing help to B cells allowing the formation of germinal center and the subsequent long-lived plasma cells differentiation. There is a growing body of evidence by far pointing toward the crucial roles of TFH cells in the overproduction of pathogenic autoantibodies and tissue damages in SLE. This article concerns the expansion and pathogenic mechanisms of TFH cells in SLE, and in particular, potential therapeutic implications for targeting TFH cells in this immunopathologically complicated disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autoimmunity Reviews - Volume 10, Issue 6, April 2011, Pages 299–304
نویسندگان
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