کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3342159 | 1214268 | 2010 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The geoepidemiology of autoimmune muscle disease The geoepidemiology of autoimmune muscle disease](/preview/png/3342159.png)
Dermatomyositis (DM), polymyositis (PM), and sporadic inclusion-body myositis (sIBM) constitute a heterogeneous group of subacute or chronic acquired skeletal muscle diseases.Known as idiopathic inflammatory myopathies (IIM), they all share the presence of considerable weakness due to muscle inflammation and necrosis.Diagnosis is based on clinical findings, confirmed by laboratory examinations (serum muscle enzyme concentrations, autoantibodies against nuclear or cytoplasmatic antigens, electromyography, and muscle biopsy).Environmental exposures leading to immune activation in genetically susceptible individuals seem to be a probable pathogenic mechanism.Infectious agents, drugs, and ultraviolet radiation have been identified as a cause of the onset, exacerbation, or acceleration of these myopathies.Several case reports and population studies have been reported to support the relationship between inflammatory myopathy and the environment. Moreover, seasonal patterns of the onset of IIM have frequently been reported.
Journal: Autoimmunity Reviews - Volume 9, Issue 5, March 2010, Pages A330–A334