کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3342248 | 1214273 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The therapeutic potential of targeting B cells and anti-oxLDL antibodies in atherosclerosis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The therapeutic potential of targeting B cells and anti-oxLDL antibodies in atherosclerosis The therapeutic potential of targeting B cells and anti-oxLDL antibodies in atherosclerosis](/preview/png/3342248.png)
چکیده انگلیسی
While the involvement of T cells in atherosclerosis is nowadays well accepted, little is known about the role of B cells. Obviously, B cells as the source of antibodies, in particular antibodies to oxLDL, have gained a lot of attention in atherosclerosis. In addition, B cells do harbour other functions in adaptive immunity. In this review, we provide an overview of the current knowledge on both the role of B cells and antibodies, i.e., anti-oxLDL antibodies, in atherosclerosis. It appears that B cells and also anti-oxLDL antibodies may comprise pro- and anti-atherogenic effects. Therefore, the establishment of effective therapy, targeting B cells or anti-oxLDL antibodies, warrants further research to unravel these opposite effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autoimmunity Reviews - Volume 9, Issue 1, September 2009, Pages 53–57
Journal: Autoimmunity Reviews - Volume 9, Issue 1, September 2009, Pages 53–57
نویسندگان
M. van Leeuwen, J. Damoiseaux, A. Duijvestijn, J.W. Cohen Tervaert,