کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3342439 | 1214286 | 2008 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Recurrent pericarditis: Infectious or autoimmune? Recurrent pericarditis: Infectious or autoimmune?](/preview/png/3342439.png)
The etiology and pathogenesis of idiopathic recurrent acute pericarditis (IRAP) remain controversial standing like a bridge that crosses infectious, autoimmune and autoinflammatory pathways. Anything may cause acute pericarditis; Echo-virus, and Coxsackie are the most frequently involved viruses, Mycobacterium tuberculosis and Coxiella burnetii the most common bacteria, but in 85% of cases it remains “idiopathic”. Recurrences occur in up to 20–50% of patients. An immuno-mediated pathogenesis is suggested by the presence of pro-inflammatory cytokines in pericardial fluid, the presence of antinuclear autoantibodies (ANA) in sera of the patients, the occurrence of new autoimmune diagnoses and the good response to anti-inflammatory or immunosuppressive therapy. Nonsteroidal anti-inflammatory drugs (NSAIDs) must be used at recommended dosages, till the resolution of symptoms and normalization of C-reactive protein and erythrocyte sedimentation rate. Corticosteroids should be used rarely, at low doses, with an extremely low tapering and with osteoporosis prevention. Colchicine leads to a clinically important and statistically significant benefit, reducing recurrences by 50%.The long term outcome of IRAP is good, without evidence of constriction even after a very long follow-up.
Journal: Autoimmunity Reviews - Volume 8, Issue 1, October 2008, Pages 44–47