کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3342723 | 1214306 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The role of the X chromosome in immunity and autoimmunity
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Primary immunodeficiencies as well as autoimmune diseases have been associated to X chromosome abnormalities. Furthermore, the functional biology of the X chromosome is unique because genes located in this chromosome can undergo inactivation, and subsequently transcriptional silencing. Non-random X chromosome inactivation has been hypothesized to be involved in the development of autoimmunity. Recently X chromosome monosomy has also been proposed as a common etiologic mechanism for some autoimmune diseases. Herein, we review some of these findings above mentioned.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autoimmunity Reviews - Volume 6, Issue 4, March 2007, Pages 218–222
Journal: Autoimmunity Reviews - Volume 6, Issue 4, March 2007, Pages 218–222
نویسندگان
Gabriela Hernández-Molina, Yevgeniya Svyryd, Jorge Sánchez-Guerrero, Osvaldo M. Mutchinick,