کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3343420 1214418 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hormonal deprivation therapy-induced osteoporosis in postmenopausal women with breast cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ایمونولوژی، آلرژی و روماتولوژی
پیش نمایش صفحه اول مقاله
Hormonal deprivation therapy-induced osteoporosis in postmenopausal women with breast cancer
چکیده انگلیسی

Aromatase inhibitor (AI) therapy significantly increases the disease-free survival in postmenopausal patients with hormone receptor-positive breast cancer. AIs are potent inhibitors of oestradiol production. Large adjuvant trials showed that the third-generation AIs (i.e., anastrozole, letrozole and exemestane) are risk factors for an increased bone loss, and are associated with an increase in the risk of fractures in women with bone fragility. A comprehensive assessment of risk of fractures must be performed at the initiation of an AI therapy. Antiresorptive drugs (i.e., bisphosphonates and denosumab) are effective for bone loss prevention and treatment in these patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Best Practice & Research Clinical Rheumatology - Volume 23, Issue 6, December 2009, Pages 805–811
نویسندگان
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