کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3344920 1214886 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Is That Staphylococcus aureus Isolate Really Methicillin Susceptible?
ترجمه فارسی عنوان
آیا استافیلوکوکوس اورئوس جداسازی واقعا متیسییلین حساس است؟
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
چکیده انگلیسی

The increased use of molecular diagnostic methods for the detection of methicillin-resistant Staphylococcus aureus (MRSA) has led to more frequent reports of mecA-positive, oxacillin-susceptible S. aureus (OS-MRSA) strains. This poses a dilemma for the laboratory, which must choose between reporting phenotypic or genotypic results as the best indicator for clinical response. Recent studies have demonstrated that phenotypic expression of oxacillin resistance can be “induced” in some OS-MRSA strains, either by a true induction mechanism or through the selection of mutations in a heterogeneously oxacillin-resistant strain, which results in an increased percentage of cells expressing oxacillin resistance. Thus, additional testing may be warranted when phenotypic and genotypic methods for oxacillin resistance disagree to avoid treating patients with antimicrobial agents that may prove ineffective.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Microbiology Newsletter - Volume 37, Issue 10, 15 May 2015, Pages 79–84
نویسندگان
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