کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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334530 | 546567 | 2011 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Cellular pathology within the anterior cingulate cortex of patients with late-life depression: A morphometric study Cellular pathology within the anterior cingulate cortex of patients with late-life depression: A morphometric study](/preview/png/334530.png)
Previous imaging and morphometric studies have identified volumetric and cellular abnormalities in prefrontal areas in late-life depression. This study aimed to examine cellular morphology using stereological methodology in the supragenual region of the anterior cingulate cortex in late-life depressed patients compared with age-matched controls. Post-mortem tissue was acquired from nine patients with depression and 11 control patients and analyzed using the optical disector and nucleator methods. No changes were found in glial, non-pyramidal and pyramidal cell density, or in non-pyramidal or pyramidal cell volume within individual layers (2–5) or the supragenual anterior cortex as a whole. This study, therefore, does not provide further evidence for cellular abnormalities in late-life depression.
Journal: Psychiatry Research: Neuroimaging - Volume 194, Issue 2, 30 November 2011, Pages 184–189