کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3346868 | 1215916 | 2015 | 6 صفحه PDF | دانلود رایگان |
• K. pneumoniae were collected from intra-abdominal infections in Latin America (2008–2012) as part of the Study for Monitoring Antimicrobial Resistance Trends.
• Antimicrobial susceptibility patterns and beta-lactamase content were determined.
• The proportion of phenotypically ESBL+ isolates did not change significantly (~42%).
• Susceptibility to cephalosporins and carbapenems decreased in all and ESBL+ isolates.
• Trend analysis revealed an increase in isolates encoding KPC or both KPC and an ESBL.
The Study for Monitoring Antimicrobial Resistance Trends has monitored the in vitro activity of several recommended antimicrobials used in the management of intra-abdominal infections (IAIs) globally since 2002. In this report, we document the changing susceptibility patterns to recommended antimicrobials in Klebsiella pneumoniae isolates from patients with IAIs in 11 Latin American countries between 2008 and 2012 and describe the beta-lactamases encoded by phenotypically extended-spectrum beta-lactamase (ESBL)–positive and ertapenem-nonsusceptible isolates. Overall, the incidence of phenotypically ESBL-positive K. pneumoniae did not change significantly from 2008 (40.4%) to 2012 (41.2%) (P > 0.05). However, trend analysis documented an increase in isolates encoding K. pneumoniae carbapenemase (KPC) or both KPC and an ESBL. Decreasing susceptibility (P < 0.05) was noted for cefepime, ceftazidime, ceftriaxone, ertapenem, and imipenem among all K. pneumoniae, as well as for cefepime, cefotaxime, cefoxitin, ceftriaxone, ertapenem, and imipenem among ESBL-positive isolates, while susceptibility of ESBL-negative isolates to ampicillin-sulbactam actually increased (P < 0.05).
Journal: Diagnostic Microbiology and Infectious Disease - Volume 82, Issue 3, July 2015, Pages 209–214