کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
334733 546653 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evidence for smaller right amygdala volumes in posttraumatic stress disorder following childhood trauma
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Evidence for smaller right amygdala volumes in posttraumatic stress disorder following childhood trauma
چکیده انگلیسی


• Bilateral amygdala and hippocampus were segmented and volumes compared.
• Right amygdala was smaller in PTSD patients with a history of childhood trauma.
• Smaller volumes were specific for the basolateral and centromedial amygdala nuclei.
• No differences found in hippocampal volumes.
• Further evidence for smaller amygdala volumes in PTSD related to childhood Trauma.

Hippocampus and amygdala volumes in posttraumatic stress disorder (PTSD) related to childhood trauma are relatively understudied, albeit the potential importance to the disorder. Whereas some studies reported smaller hippocampal volumes, little evidence was found for abnormal amygdala volumes. Here we investigated hippocampus and amygdala volumes and shapes in an adult sample of PTSD patients related to childhood trauma. T1-weighted MR images were acquired from 12 female PTSD patients with trauma related to physical, sexual, and/or emotional abuse before age 18, and from 12 matched controls. Hippocampus and amygdala were segmented, and volumes were calculated and corrected for the total intracranial volume. Additionally, a shape analysis was done on the surface of the structures to explore abnormalities in specific subnuclei. Smaller right amygdala volumes were found in PTSD patients as compared with the controls. This difference appeared to be located specifically in the basolateral and superficial nuclei groups. Severity of sexual abuse during childhood was negatively correlated with the size of the amygdala. No difference in hippocampal volumes was found. Although our results are not conclusive, traumatic events in childhood might impede normal development of the amygdala, which could render a person more vulnerable to develop PTSD later in life.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 233, Issue 3, 30 September 2015, Pages 436–442
نویسندگان
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