کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3348262 1216005 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The impact of multidrug resistance on the outcomes of critically ill patients with Gram-negative bacterial pneumonia
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
The impact of multidrug resistance on the outcomes of critically ill patients with Gram-negative bacterial pneumonia
چکیده انگلیسی

Multidrug resistance (MDR) in Gram-negative bacteria is on the rise, but its effect on patient outcomes is not well established. The outcomes of 129 adult surgical intensive care unit (SICU) patients treated for Gram-negative pneumonia were evaluated in relation to demographics, bacterial etiology, and infections due to MDR bacteria (defined as resistant to all agents except for aminoglycosides and polymyxins). The mean (SD) age and acute physiology and chronic health evaluation (APACHE) II scores were 63.8 (14.6) years and 20.8 (8.2), respectively. Forty-one patients (31.8%) were infected with MDR bacteria. Infection-attributed mortality was associated with baseline APACHE II scores (odds ratio [OR] 1.093; 95% confidence interval [CI] 1.029–1.162), MDR (OR 4.628; 95% CI 1.533–13.973), and infection with Stenotrophomonas maltophilia (OR 13.465; 95% CI 2.896–62.614). In SICU patients with Gram-negative pneumonia, MDR was associated with a higher rate of infection-attributed mortality, after adjusting for the severity of illness. Our results warrant further investigations with a prospective study.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diagnostic Microbiology and Infectious Disease - Volume 58, Issue 1, May 2007, Pages 99–104
نویسندگان
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